Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

@article{Sato2006RegulationOO,
  title={Regulation of osteoclast differentiation and function by the CaMK-CREB pathway},
  author={Kojiro Sato and Ayako Suematsu and Tomoki Nakashima and Sayaka Takemoto-Kimura and Kazuhiro Aoki and Yasuyuki Morishita and Hiroshi Asahara and Keiichi Ohya and Akira Yamaguchi and Toshiyuki Takai and Tatsuhiko Kodama and Talal A Chatila and Haruhiko Bito and Hiroshi Takayanagi},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={1410-1416}
}
Calcium (Ca2+) signaling is essential for a variety of cellular responses and higher biological functions. Ca2+/calmodulin-dependent kinases (CaMKs) and the phosphatase calcineurin activate distinct downstream pathways that are mediated by the transcription factors cAMP response element (CRE)-binding protein (CREB) and nuclear factor of activated T cells (NFAT), respectively. The importance of the calcineurin-NFAT pathway in bone metabolism has been demonstrated in osteoclasts, osteoblasts and… CONTINUE READING
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