Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.

@article{Geier2002RegulationOO,
  title={Regulation of organic anion transporters in a new rat model of acute and chronic cholangitis resembling human primary sclerosing cholangitis.},
  author={Andreas Geier and Christoph G. Dietrich and Frank Lammert and Thomas L Orth and W. J. Mayet and Siegfried Matern and Carsten Gartung},
  journal={Journal of hepatology},
  year={2002},
  volume={36 6},
  pages={718-24}
}
BACKGROUND/AIMS Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiology. Although the primary defect affects cholangiocytes, cholestatic injury of hepatocytes may promote further liver damage. Since down-regulation of hepatocellular organic anion transporters is implicated in the molecular pathogenesis of cholestasis… CONTINUE READING