Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors.

@article{Mcmorris1993RegulationOO,
  title={Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factors.},
  author={F. Arthur Mcmorris and Robin L. Mozell and Monica Joanne Carson and Y. Shinar and Rosana D. Meyer and Nella Marchetti},
  journal={Annals of the New York Academy of Sciences},
  year={1993},
  volume={692},
  pages={
          321-34
        }
}
In summary, our studies show that IGFs are potent regulators of oligodendrocyte development and myelination in vitro and in vivo. IGFs act at several levels: by promoting proliferation of oligodendrocytes and oligodendrocyte precursors, by inducing immature oligodendrocyte precursors to develop into oligodendrocytes, and by regulating myelin gene expression and the amount of myelin produced per oligodendrocyte. Our findings indicate that IGFs play a crucial role in normal oligodendrocyte… CONTINUE READING
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