Regulation of nucleolar signalling to p53 through NEDDylation of L11

@article{Sundqvist2009RegulationON,
  title={Regulation of nucleolar signalling to p53 through NEDDylation of L11},
  author={A. Sundqvist and Geng-Hung Liu and Antonis Mirsaliotis and D. Xirodimas},
  journal={EMBO reports},
  year={2009},
  volume={10}
}
Several studies have shown that ribosomal proteins (RPs) are important mediators of p53 activation in response to nucleolar disruption; however, the pathways that control this signalling function of RPs are currently unknown. We have recently shown that RPs are targets for the ubiquitin‐like molecule NEDD8, and that NEDDylation protects RPs from destabilization. Here, we identify NEDD8 as a crucial regulator of L11 RP signalling to p53. A decrease in L11 NEDDylation during nucleolar stress… Expand
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