Regulation of nuclear transport: central role in development and transformation?

@article{Poon2005RegulationON,
  title={Regulation of nuclear transport: central role in development and transformation?},
  author={Ivan K H Poon and David Andrew Jans},
  journal={Traffic},
  year={2005},
  volume={6 3},
  pages={173-86}
}
Transport of macromolecules into and out of the nucleus is generally effected by targeting signals that are recognized by specific members of the importin/exportin transport receptor family. The latter mediate passage through the nuclear envelope-embedded nuclear pore complexes (NPCs) by conferring interaction with NPC constituents, as well as with other components of the nuclear transport machinery, including the guanine nucleotide-binding protein Ran. Importantly, nuclear transport is… CONTINUE READING
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