Regulation of nuclear factor-κB in autoimmunity.

  title={Regulation of nuclear factor-κB in autoimmunity.},
  author={Shao-Cong Sun and Jae-Hoon Chang and Jin Jin},
  journal={Trends in immunology},
  volume={34 6},
Nuclear factor (NF)-κB transcription factors are pivotal regulators of innate and adaptive immune responses, and perturbations of NF-κB signaling contribute to the pathogenesis of immunological disorders. NF-κB is a well-known proinflammatory mediator, and its deregulated activation is associated with the chronic inflammation of autoimmune diseases. Paradoxically, NF-κB plays a crucial role in the establishment of immune tolerance, including both central tolerance and the peripheral function of… CONTINUE READING
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