Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle.

@article{Williams1986RegulationON,
  title={Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle.},
  author={R. Sanders Williams and Stanley Salmons and Eric A. Newsholme and Russel E. Kaufman and Jane Mellor},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 1},
  pages={376-80}
}
Increased contractile activity of skeletal muscle augments the volume fraction and enzymatic capacity of mitochondria and suppresses the enzymatic capacity of several cytoplasmic enzymes of glycolysis. To examine the biochemical mechanisms underlying these effects, we measured the concentrations of cytochrome b mRNA and aldolase A mRNA in tibialis anterior muscles of adult rabbits that had been stimulated via the motor nerve to contract continuously at 10 Hz for 5 or 21 days; these were… CONTINUE READING

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Muscle Nerve

  • B. Saltin, P. D. Gollnick
  • Annu. Reu. Physiol
  • 1976

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