Regulation of nonsense-mediated mRNA decay: implications for physiology and disease.

@article{Karam2013RegulationON,
  title={Regulation of nonsense-mediated mRNA decay: implications for physiology and disease.},
  author={Rachid Karam and Jordan C. Wengrod and Lawrence B. Gardner and Miles F. Wilkinson},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1829 6-7},
  pages={624-33}
}
Nonsense-mediated mRNA decay (NMD) is an mRNA quality control mechanism that destabilizes aberrant mRNAs harboring premature termination (nonsense) codons (PTCs). Recent studies have shown that NMD also targets mRNAs transcribed from a large subset of wild-type genes. This raises the possibility that NMD itself is under regulatory control. Indeed, several recent studies have shown that NMD activity is modulated in specific cell types and that key components of the NMD pathway are regulated by… CONTINUE READING
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