Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation.

@article{Vitturi2009RegulationON,
  title={Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation.},
  author={Dario A. Vitturi and Xinjun Teng and Jos{\'e} Carlos Toledo and Sadis Matalon and Jack R. Lancaster and Rakesh P Patel},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={296 5},
  pages={H1398-407}
}
Allosteric regulation of nitrite reduction by deoxyhemoglobin has been proposed to mediate nitric oxide (NO) formation during hypoxia. Nitrite is predominantly an anion at physiological pH, raising questions about the mechanism by which it enters the red blood cell (RBC) and whether this is regulated and coupled to deoxyhemoglobin-mediated reduction. We tested the hypothesis that nitrite transport by RBCs is regulated by fractional saturation. Using human RBCs, nitrite consumption was faster at… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Comparative analysis of nitrite uptake and hemoglobin-nitrite reactions in erythrocytes: sorting out uptake mechanisms and oxygenation dependencies.

American journal of physiology. Regulatory, integrative and comparative physiology • 2010
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Nitrite consumption in ischemic rat heart catalyzed by distinct blood-borne and tissue factors.

American journal of physiology. Heart and circulatory physiology • 2008
View 1 Excerpt

Similar Papers

Loading similar papers…