Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV- associated neurological disease

@article{Bukrinsky1995RegulationON,
  title={Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV- associated neurological disease},
  author={Michael I. Bukrinsky and Hans SLM Nottet and Helena Schmidtmayerova and Larisa Dubrovsky and Constance Flanagan and Michael E Mullins and Stuart Lipton and Howard E. Gendelman},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={181},
  pages={735 - 745}
}
Mononuclear phagocytes (monocytes, macrophages, and dendritic cells) play major roles in human immunodeficiency virus (HIV) persistence and disease pathogenesis. Macrophage antigen presentation and effector cell functions are impaired by HIV-1 infection. Abnormalities of macrophage effector cell function in bone marrow, lung, and brain likely result as a direct consequence of cellular activation and HIV replication. To further elucidate the extent of macrophage dysfunction in HIV-1 disease, a… CONTINUE READING

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Platelet - activating factor : a candidate human immunodeficiency virus type 1 - induced neurotoxin

  • K. Dzenko, R. W. Keane, L. Resnick, Y. Mizrachi
  • 1994

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