Regulation of nitric oxide and soluble guanylyl cyclase.

  title={Regulation of nitric oxide and soluble guanylyl cyclase.},
  author={Joshua S. Krumenacker and Khalid A. Hanafy and Ferid Murad},
  journal={Brain research bulletin},
  volume={62 6},
Since the discoveries that have verified nitric oxide (NO) as an endogenously produced cell signaling molecule, research surrounding its production and mechanisms of action have been studied at an exponentially increasing rate. NO is produced by a family of enzymes termed the NO synthases (NOS), which are regulated independently by various stimuli. Once produced, NO can solicit numerous biological events by reacting with various metals, thiols, and oxygen species to modify proteins, DNA and… CONTINUE READING