Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels

@article{Wei2015RegulationON,
  title={Regulation of neuropathic pain behavior by amygdaloid TRPC4/C5 channels},
  author={Hong Wei and Boriss Sagalajev and M Anil Y{\"u}zer and A. Koivisto and Antti Pertovaara},
  journal={Neuroscience Letters},
  year={2015},
  volume={608},
  pages={12-17}
}
Pain per se may increase anxiety and conversely, anxiety may increase pain. Therefore, a positive feedback loop between anxiety and pain possibly contributes to pain and suffering in some pathophysiological pain conditions, such as that induced by peripheral nerve injury. Recent results indicate that transient receptor channels 4 and 5 (TRPC4/C5) in the amygdala have anxiogenic effects in rodents, while their role in chronic pain conditions is not known. Here, we studied whether the amygdaloid… CONTINUE READING

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