Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5

@inproceedings{Finegan2009RegulationON,
  title={Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5},
  author={Katherine G. Finegan and Xin Wang and Eun-ju Lee and Andrew C. Robinson and Cathy Tournier},
  booktitle={Cell Death and Differentiation},
  year={2009}
}
The extracellular signal-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase that phosphorylates and regulates various transcription factors in response to growth factors and extracellular stresses. To address its biological function during the development of the peripheral nervous system (PNS), we have engineered a novel model of sympathetic neurons in which the erk5 gene can be deleted in vitro. Our data provide for the first time genetic evidence that ERK5 is required to… CONTINUE READING
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A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside

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  • J Neurosci
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