Regulation of neuronal excitability by release of proteins from glial cells.

@article{Igelhorst2015RegulationON,
  title={Regulation of neuronal excitability by release of proteins from glial cells.},
  author={Birte A. Igelhorst and Vanessa Niederkinkhaus and Claudia Karus and Maren Denise Lange and Irmgard D. Dietzel},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2015},
  volume={370 1672}
}
Effects of glial cells on electrical isolation and shaping of synaptic transmission between neurons have been extensively studied. Here we present evidence that the release of proteins from astrocytes as well as microglia may regulate voltage-activated Na(+) currents in neurons, thereby increasing excitability and speed of transmission in neurons kept at distance from each other by specialized glial cells. As a first example, we show that basic fibroblast growth factor and neurotrophin-3, which… CONTINUE READING