Regulation of neuronal chloride homeostasis by neuromodulators

  title={Regulation of neuronal chloride homeostasis by neuromodulators},
  author={Vivek Mahadevan and Melanie A Woodin},
  booktitle={The Journal of physiology},
KCC2 is the central regulator of neuronal Cl(-) homeostasis, and is critical for enabling strong hyperpolarizing synaptic inhibition in the mature brain. KCC2 hypofunction results in decreased inhibition and increased network hyperexcitability that underlies numerous disease states including epilepsy, neuropathic pain and neuropsychiatric disorders. The… CONTINUE READING