Regulation of neuroD2 expression in mouse brain.

  title={Regulation of neuroD2 expression in mouse brain.},
  author={C W Lin and Jennifer Stoeck and Ali C. Ravanpay and François Guillemot and Stephen J. Tapscott and James M. Olson},
  journal={Developmental biology},
  volume={265 1},
The basic helix-loop-helix (bHLH) transcription factor, neuroD2, induces neuronal differentiation and promotes neuronal survival. Reduced levels of neuroD2 were previously shown to cause motor deficits, ataxia, and seizure propensity. Because neuroD2 levels may be critical for brain function, we studied the regulation of neuroD2 gene in cell culture and transgenic mouse models. In transgenic mice, a 10-kb fragment of the neuroD2 promoter fully recapitulated the endogenous neuroD2 staining… CONTINUE READING
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