Regulation of neuregulin expression in the injured rat brain and cultured astrocytes.

@article{Tokita2001RegulationON,
  title={Regulation of neuregulin expression in the injured rat brain and cultured astrocytes.},
  author={Yoshihito Tokita and Hiroomi Keino and Fumiko Matsui and Sachiko Aono and Hiroshi Ishiguro and Shigeki Higashiyama and Atsuhiko Oohira},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 4},
  pages={
          1257-64
        }
}
In this report, we investigated whether reactive astrocytes produce neuregulins (glial growth factor 2/heregulin/acetylcholine receptor-inducing activity or neu differentiation factor) and its putative receptors, ErbB2 and ErbB3 tyrosine kinases, in the injured CNS in vivo. Significant immunoreactivities with anti-neuregulin, anti-ErbB2, and anti-ErbB3 antibodies were detected on astrocytes at the injured site 4 d after injury to the adult rat cerebral cortex. To elucidate the mechanisms for… CONTINUE READING

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