Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development.

@article{Wang2008RegulationON,
  title={Regulation of neural progenitor cell motility by ceramide and potential implications for mouse brain development.},
  author={Guanghu Wang and Kannan Krishnamurthy and Ying-Wei Chiang and Somsankar Dasgupta and Erhard Bieberich},
  journal={Journal of neurochemistry},
  year={2008},
  volume={106 2},
  pages={
          718-33
        }
}
We provide evidence that the sphingolipid ceramide, in addition to its pro-apoptotic function, regulates neural progenitor (NP) motility in vitro and brain development in vivo. Ceramide (N-palmitoyl d-erythro sphingosine and N-oleoyl d-erythro sphingosine) and the ceramide analog N-oleoyl serinol (S18) stimulate migration of NPs in scratch (wounding) migration assays. Sphingolipid depletion by inhibition of de novo ceramide biosynthesis, or ceramide inactivation using an anti-ceramide antibody… CONTINUE READING
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