Regulation of netrin-1 receptors by amphetamine in the adult brain.

  title={Regulation of netrin-1 receptors by amphetamine in the adult brain.},
  author={Leora Yetnikoff and Cassandre Labelle-Dumais and Cynthia Flores},
  volume={150 4},
Netrin-1 is a guidance cue molecule fundamental to the organization of neuronal connectivity during development. Netrin-1 and its receptors, deleted in colorectal cancer (DCC) and UNC-5 homologues (UNC-5), continue to be expressed in the adult brain, although neither their function nor the kinds of events that activate their expression are known. Two lines of evidence suggest a role for netrin-1 in amphetamine-induced dopamine plasticity in the adult. First, DCC is highly expressed by adult… CONTINUE READING

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