Regulation of nerve growth factor release by nitric oxide through cyclic GMP pathway in cortical glial cells.

@article{Xiong1999RegulationON,
  title={Regulation of nerve growth factor release by nitric oxide through cyclic GMP pathway in cortical glial cells.},
  author={Hui Xiong and Katsuya Yamada and Hussam Jourdi and Masaki Kawamura and Norio Takei and Dong Han and Toshitaka Nabeshima and Hiroyuki Nawa},
  journal={Molecular pharmacology},
  year={1999},
  volume={56 2},
  pages={339-47}
}
In the present study, we found that S-nitroso-N-acetyl-DL-penicillamine, a spontaneous nitric oxide (NO) generator, dose-dependently inhibited basal nerve growth factor (NGF) release from mixed glial cells. To elucidate the function of endogenous NO in the regulation of NGF release, the mixed glial cells were stimulated with lipopolysaccharide (LPS) or LPS plus interferon-gamma (IFNgamma). The results showed that LPS alone induced NGF release and moderate NO production. However, costimulation… CONTINUE READING

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