Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains.

@article{Hill2003RegulationOM,
  title={Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains.},
  author={Jennifer J. Hill and Yongchang Qiu and Rodney M. Hewick and Neil M. Wolfman},
  journal={Molecular endocrinology},
  year={2003},
  volume={17 6},
  pages={1144-54}
}
Myostatin, a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene (FLRG). Here, we report the identification of an additional protein associated with endogenous myostatin in normal mouse and human serum, discovered by affinity purification and mass spectrometry. This protein, which we have named growth and differentiation… CONTINUE READING

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A human protein containing multiple types of protease-inhibitory modules.

Proceedings of the National Academy of Sciences of the United States of America • 2001

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