Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.

@article{Hirano2004RegulationOM,
  title={Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.},
  author={Katsuya Hirano and Mayumi Hirano and Hideo Kanaide},
  journal={Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi},
  year={2004},
  volume={40 6},
  pages={219-36}
}
The Ca2+-dependent, reversible phosphorylation of the 20 kDa regulatory myosin light chain (MLC) plays a primary role in regulating the contraction of smooth muscle. However, it is well known that the Ca2+ signal is not the only factor which regulates such contraction, however, the alteration of the Ca2+ sensitivity in the contractile apparatus is also known to play an important role. The degree of MLC phosphorylation is determined by the balance of the activity between phosphorylation and… CONTINUE READING

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