Regulation of myosin heavy chain genes in the heart.

@article{Morkin1993RegulationOM,
  title={Regulation of myosin heavy chain genes in the heart.},
  author={Eugene Morkin},
  journal={Circulation},
  year={1993},
  volume={87 5},
  pages={1451-60}
}
Advances in our knowledge of the regulation of cardiac myosin isoforms made possible by molecular cloning of the alpha- and beta-MHCs genes are reviewed. Expression of these genes in heart does not seem to require MyoD or related proteins of the skeletal muscle myogenic program. Cardiac MHC genes are under the control of T3, which stimulates transcription of the alpha-MHC gene and inhibits beta-MHC mRNA production both in vivo and in cultured heart cells. The responsiveness of the genes to T3… CONTINUE READING
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