Regulation of myocardial contractility.

  title={Regulation of myocardial contractility.},
  author={Lionel Henry Opie},
  journal={Journal of cardiovascular pharmacology},
  volume={26 Suppl 1},
The definition of myocardial contractility remains complex and its exact measurement remains difficult, especially in the intact heart. Measurement of load-independent effects requires sophisticated equipment and preparations that are not applicable to clinical practice. At present, the more attractive concept is to think in terms of the calcium-contractile protein interaction, especially at the level of calcium-troponin-C. Either an increased supply of calcium is required to bind to the… CONTINUE READING


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