Regulation of myelopoiesis by the transcription factor IRF8

@article{Tamura2015RegulationOM,
  title={Regulation of myelopoiesis by the transcription factor IRF8},
  author={Tomohiko Tamura and Daisuke Kurotaki and Shinji Koizumi},
  journal={International Journal of Hematology},
  year={2015},
  volume={101},
  pages={342-351}
}
Interferon regulatory factor-8 (IRF8) is a transcription factor expressed in hematopoietic cells, particularly in mononuclear phagocytes [monocytes/macrophages and dendritic cells (DCs)] and their progenitors. Various studies have demonstrated that IRF8 is essential for the development of monocytes, DCs, eosinophils, and basophils. Conversely, IRF8 suppresses the generation of neutrophils. Accordingly, Irf8−/− mice develop immunodeficiency and a chronic myeloid leukemia (CML)-like disease… Expand
Interferon regulatory factor 8 and the regulation of neutrophil, monocyte, and dendritic cell production
TLDR
This review discusses recent studies that have revealed molecular mechanisms underlying the regulation of myelopoiesis by IRF8, which cooperates with other transcription factors to control the initiation of gene expression programs that define the development of specific myeloid cell subsets. Expand
Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8.
  • D. Kurotaki, T. Tamura
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2016
TLDR
Recent advances in the understanding of transcriptional and epigenetic regulation involving IRF8 in the development of myeloid cells are discussed. Expand
A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
TLDR
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TLDR
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TLDR
The existence in vivo of a new lineage of osteoclast precursors among BMCs, which differentiate into osteoclasts without up-regulation of Lyz2 expression is proposed. Expand
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TLDR
The hypothesis that interferon regulatory factor-8 (IRF8) is an integral negative regulator of MDSCs biology is supported by observations that enforced expression of IRF8 in the myeloid system significantly mitigates tumor-induced MDSC accumulation and improves immunotherapy efficacy. Expand
IFN regulatory factor-8 expression in macrophages governs an antimetastatic program.
TLDR
Overall, the findings reveal a previously unrecognized role for IRF8 in macrophage biology to control metastasis or predict outcome, and suggest that incorporatingIRF8 expression levels within a broadermacrophage signature or profile strengthens prognostic merit. Expand
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TLDR
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TLDR
Irf8(-/-) haematopoietic progenitors not only bestows monocyte and DC differentiation potential upon mononuclear phagocytes but also restrains these progenitor from differentiating into neutrophils. Expand
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TLDR
It is shown that during IRF8-dependent monocyte differentiation, IRf8 binding occurs at both promoter-proximal and promotor-distal regions together with the transcription factor PU and is associated with gene induction. Expand
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TLDR
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It is demonstrated that interferon regulatory factor-8 (IRF8), a transcription factor essential for the development of several myeloid lineages, also regulates basophil and mast cell development and that GATA2, a transcription factors known to promote basophils and mast cells differentiation, acts downstream of IRF8. Expand
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