Regulation of muscle protein synthesis during sepsis and inflammation.

@article{Lang2007RegulationOM,
  title={Regulation of muscle protein synthesis during sepsis and inflammation.},
  author={Charles H. Lang and Robert A. Frost and Thomas C. Vary},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={293 2},
  pages={
          E453-9
        }
}
  • C. Lang, R. Frost, T. Vary
  • Published 1 August 2007
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
Prolonged sepsis and exposure to an inflammatory milieu decreases muscle protein synthesis and reduces muscle mass. As a result of its ability to integrate diverse signals, including hormones and nutrients, the mammalian target of rapamycin (mTOR) is a dominant regulator in the translational control of protein synthesis. Under postabsorptive conditions, sepsis decreases mTOR kinase activity in muscle, as evidenced by reduced phosphorylation of both eukaryotic initiation factor (eIF)4E-binding… 

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TLDR
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Inhibition of Glycogen Synthase Kinase 3&bgr; Activity with Lithium In Vitro Attenuates Sepsis-Induced Changes in Muscle Protein Turnover
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