Regulation of muscle mass by growth hormone and IGF-I.

  title={Regulation of muscle mass by growth hormone and IGF-I.},
  author={Cristina P Velloso},
  journal={British journal of pharmacology},
  volume={154 3},
Growth hormone (GH) is widely used as a performance-enhancing drug. One of its best-characterized effects is increasing levels of circulating insulin-like growth factor I (IGF-I), which is primarily of hepatic origin. It also induces synthesis of IGF-I in most non-hepatic tissues. The effects of GH in promoting postnatal body growth are IGF-I dependent, but IGF-I-independent functions are beginning to be elucidated. Although benefits of GH administration have been reported for those who suffer… CONTINUE READING
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