Regulation of muscle growth by multiple ligands signaling through activin type II receptors.

@article{Lee2005RegulationOM,
  title={Regulation of muscle growth by multiple ligands signaling through activin type II receptors.},
  author={Se-Jin Lee and Lori Ann Reed and Monique V. Davies and Stefan Girgenrath and Mary E.P. Goad and Daniel S. Greenspan and J. Fraser Wright and Christopher H. Barker and Gregory Ehrmantraut and James Holmstrom and Betty Trowell and Barry Gertz and Man-Shiow Jiang and Suzanne M Sebald and Martin Matzuk and En Li and Li-fang Liang and Edwin Quattlebaum and Ronald L. Stotish and Neil M. Wolfman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 50},
  pages={
          18117-22
        }
}
Myostatin is a secreted protein that normally functions as a negative regulator of muscle growth. Agents capable of blocking the myostatin signaling pathway could have important applications for treating human muscle degenerative diseases as well as for enhancing livestock production. Here we describe a potent myostatin inhibitor, a soluble form of the activin type IIB receptor (ACVR2B), which can cause dramatic increases in muscle mass (up to 60% in 2 weeks) when injected into wild-type mice… CONTINUE READING

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