Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction.

  title={Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction.},
  author={T R Leonard and W Herzog},
  journal={American journal of physiology. Cell physiology},
  volume={299 1},
For the past half century, the sliding filament-based cross-bridge theory has been the cornerstone of our understanding of how muscles contract. According to this theory, active force can only occur if there is overlap between the contractile filaments, actin and myosin. Otherwise, forces are thought to be caused by passive structural elements and are assumed to vary solely because of the length of the muscle. We observed increases in muscle force by a factor of 3 to 4 above the purely passive… CONTINUE READING
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Active and passive myofibrils lengthened beyond acto-myosin filament overlap produce different forces (Abstract)

  • TR Leonard, V Joumaa, W. Herzog
  • Biophys J 96,
  • 2009
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