Regulation of muscle fiber type and running endurance by PPARdelta.

Abstract

Endurance exercise training can promote an adaptive muscle fiber transformation and an increase of mitochondrial biogenesis by triggering scripted changes in gene expression. However, no transcription factor has yet been identified that can direct this process. We describe the engineering of a mouse capable of continuous running of up to twice the distance… (More)

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@article{Wang2004RegulationOM, title={Regulation of muscle fiber type and running endurance by PPARdelta.}, author={Yong-Xu Wang and Chun-Li Zhang and Ruth T Yu and Helen K. Cho and Michael C. Nelson and Corinne R. Bayuga-Ocampo and Jungyeob Ham and Heonjoong Kang and Ronald M Evans}, journal={PLoS biology}, year={2004}, volume={2 10}, pages={e294} }