Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase.

@article{Zheng2001RegulationOM,
  title={Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase.},
  author={Dan Zheng and Paul S. MacLean and Steven C Pohnert and John B. Knight and Ann Louise Olson and William W. Winder and G. Lynis Dohm},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 3},
  pages={
          1073-83
        }
}
Skeletal muscle GLUT-4 transcription in response to treatment with 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR), a known activator of AMP-activated protein kinase (AMPK), was studied in rats and mice. The increase in GLUT-4 mRNA levels in response to a single subcutaneous injection of AICAR, peaked at 13 h in white and red quadriceps muscles but not in the soleus muscle. The mRNA level of chloramphenicol acyltransferase reporter gene which is driven by 1,154 or 895 bp of the… Expand
Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase.
TLDR
It is concluded that GEF and MEF2 mediate the AMPK-induced increase in transcription of skeletal muscle GLUT4 and increase in binding to theGLUT4 promoter within 2 h after AICAR treatment. Expand
AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.
TLDR
It is demonstrated that muscle AMPK is not required for the response of GLUT4 mRNA to exercise and denervation, and that AMPK activation might be responsible for the increase in GLut4 mRNA expression in response to exercise. Expand
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle.
TLDR
Evidence is provided that AMPK signaling is linked to the transcriptional regulation of select metabolic genes in skeletal muscle by a single-leg arterial infusion technique employed in fully conscious rats. Expand
AMP-activated protein kinase regulates the expression of monocarboxylate transporter 4 in skeletal muscle.
TLDR
It is found that AMPK activation induced expression of MCT4 in RD cells and rat skeletal muscle in a fiber-type specific manner, indicating the possible involvement of an AMPK-mediated pathway associated with MCT 4 expression in skeletal muscle. Expand
AMP-activated protein kinase activation prevents denervation-induced decline in gastrocnemius GLUT-4.
TLDR
Evidence is provided that some effects of denervation may be prevented by chemical activation of the appropriate signaling pathways as well as the extent ofDenervation-induced muscle atrophy was similar in AICAR-treated vs. saline-treated rats. Expand
Exercise-induced transcription of the muscle glucose transporter (GLUT 4) gene.
TLDR
The results suggest that the exercise-induced increase in the transcriptional activity of the human GLUT4 gene is mediated, at least in part, by element(s) within -895 bp of the promoter. Expand
Invited review: Regulation of skeletal muscle GLUT-4 expression by exercise.
  • G. Dohm
  • Biology, Medicine
  • Journal of applied physiology
  • 2002
TLDR
It is important to understand how exercise regulates GLUT-4 expression so that therapeutic strategies can be designed to increase muscle glucose disposal as a treatment for diabetes. Expand
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle.
TLDR
From these data, it appears that HDAC5, PGC-1, and p38 regulate MEF-2 and could be potential targets for modulating GLUT4 expression. Expand
Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.
TLDR
The results suggest that AMPK does not mediate contraction- Stimulated glycogen synthesis or glycogenolysis in skeletal muscle and also that acute AMPK activation leads to an increased glycolytic flux by antagonizing contraction-stimulated glycogens synthesis. Expand
α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.
TLDR
It is suggested that moderate endurance exercise promotes glucose transport, GLUT4 expression, and insulin sensitivity in skeletal muscle at least partially via activation of the alpha2 isoform of AMPK. Expand
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