Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.

@article{Skeen1996RegulationOM,
  title={Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines.},
  author={Marianne J. Skeen and Mark A. Miller and Thomas M. Shinnick and H. Kirk Ziegler},
  journal={Journal of immunology},
  year={1996},
  volume={156 3},
  pages={
          1196-206
        }
}
IL-12 is important in the host response to a variety of pathogens. It plays an adjuvant-like role in an initial immune response as well as a therapeutic role in established infections. Despite its well documented importance, comparatively little is known about the regulation of IL-12 production. In this study, we examined IL-12 production by cultured murine peritoneal macrophages from two perspectives: 1) macrophage activation in vivo, and 2) stimulation of IL-12 secretion in vitro. Macrophages… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 83 CITATIONS, ESTIMATED 42% COVERAGE

211 Citations

0102030'96'01'07'13'19
Citations per Year
Semantic Scholar estimates that this publication has 211 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…