Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.

@article{Uraushihara2003RegulationOM,
  title={Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells.},
  author={Koji Uraushihara and T. Hosokawa Kanai and Kwibeom Ko and Teruji Totsuka and Shin Makita and Ryoichi Iiyama and Tetsuya Nakamura and Mamoru Watanabe},
  journal={Journal of immunology},
  year={2003},
  volume={171 2},
  pages={708-16}
}
CD4(+)CD25(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance and prevention of autoimmune disease. However, accumulating evidence suggests that a fraction of the peripheral CD4(+)CD25(-) T cell population also possesses regulatory activity in vivo. Recently, it has been shown glucocorticoid-induced TNFR family-related gene (GITR) is predominantly expressed on CD4(+)CD25(+) regulatory T cells. In this study, we show evidence that CD4(+)GITR… CONTINUE READING
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