Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation.

@article{GoljanekWhysall2012RegulationOM,
  title={Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation.},
  author={Katarzyna Goljanek-Whysall and H{\'e}lio Pais and Tina Rathjen and Dylan Sweetman and Tam{\'a}s Dalmay and Andrea M{\"u}nsterberg},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 15},
  pages={3590-600}
}
MicroRNAs are short non-coding RNAs involved in post-transcriptional regulation of multiple messenger RNA targets. The miR-1/miR-206 family is expressed during skeletal muscle differentiation and is an integral component of myogenesis. To better understand miR-1/miR-206 function during myoblast differentiation we identified novel target mRNAs by microarray and characterized their function in C2C12 myoblasts. Candidate targets from the screen were experimentally validated together with target… CONTINUE READING