Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.

@article{Harrington2008RegulationOM,
  title={Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells.},
  author={Laura S. Harrington and Richard C. A. Sainson and Cassin Kimmel Williams and Jennifer M. Taylor and Wen Shi and Ji-liang Li and Adrian L. Harris},
  journal={Microvascular research},
  year={2008},
  volume={75 2},
  pages={144-54}
}
The Notch ligand, Dll4, is essential for angiogenesis during embryonic vascular development and is involved in tumour angiogenesis. Several recent publications demonstrated that blockade of Dll4 signalling inhibits tumour growth, suggesting that it may constitute a good candidate for anti-cancer therapy. In order to understand the role of Dll4 at the cellular level, we performed an analysis of Dll4-regulated genes in HUVECs. The genes identified included several angiogenic signalling pathways… CONTINUE READING
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