Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.

@article{Kast2002RegulationOM,
  title={Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.},
  author={Heidi R Kast and Bryan Goodwin and Paul Tarr and Stacey A. Jones and Andrew M Anisfeld and Catherine M Stoltz and Peter Tontonoz and Steve A Kliewer and Timothy M Willson and Peter A. Edwards},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 4},
  pages={2908-15}
}
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the apical membrane of the hepatocyte into the bile canaliculi. We identified MRP2 in a screen designed to isolate genes that are regulated by the farnesoid X-activated receptor (FXR, NR1H4). MRP2 mRNA levels were induced following treatment of human or rat hepatocytes with either naturally occurring (chenodeoxycholic acid) or synthetic (GW4064) FXR ligands. In addition, we… CONTINUE READING
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