Regulation of mucin genes in chronic inflammatory airway diseases.

  title={Regulation of mucin genes in chronic inflammatory airway diseases.},
  author={Judith A Voynow and Sandra J Gendler and Mary Callaghan Rose},
  journal={American journal of respiratory cell and molecular biology},
  volume={34 6},
In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive… CONTINUE READING