Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor.

@article{Galli1995RegulationOM,
  title={Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor.},
  author={Stephen J. Galli and Mindy Tsai and Barry K. Wershil and Steve Y Tam and John Costa},
  journal={International archives of allergy and immunology},
  year={1995},
  volume={107 1-3},
  pages={51-3}
}
Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell survival by suppressing apoptosis, induce mast cell hyperplasia in murine rodents, experimental primates and humans, directly induce SCFR-dependent mast cell mediator release, and significantly modulate the extent of mast cell activation by Fc epsilon RI-dependent mechanisms… CONTINUE READING

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