Regulation of mouse CD72 gene expression during B lymphocyte development.

  title={Regulation of mouse CD72 gene expression during B lymphocyte development.},
  author={Han Ying and James I. Healy and Christopher C. Goodnow and Jane R. Parnes},
  journal={Journal of immunology},
  volume={161 9},
CD72 is a 45-kDa transmembrane glycoprotein that is predominantly expressed on cells of the B lineage except plasma cells. Previously, we identified the 255-bp minimal mouse CD72 promoter capable of tissue-specific and developmental stage-specific expression. DNase I footprinting analysis of the 255-bp CD72 promoter revealed three protected elements, footprint (FP) I, FP II, and FP III. FP II, which extends from nucleotide -189 to -169 of the mouse CD72 promoter, exhibited both tissue-specific… CONTINUE READING

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