Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family.

@article{Tappe2006RegulationOM,
  title={Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family.},
  author={Anke Tappe and Rohini Kuner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 3},
  pages={774-9}
}
Intracellular calcium mobilization and signaling mechanisms triggered by activation of synaptic glutamate receptors in the striatum are important modulators of neurotransmission in striatal circuits. However, the expression and functions of scaffolding proteins anchoring glutamate receptors at striatal synapses have not been addressed so far. The long-form Homer1 proteins, Homer1b/c, assemble group I metabotropic glutamate receptors (mGluR1/5) in large macromolecular complexes with sources of… CONTINUE READING
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