Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins.

@article{William2003RegulationOM,
  title={Regulation of motor neuron subtype identity by repressor activity of Mnx class homeodomain proteins.},
  author={Christopher M. William and Yasuto Tanabe and Thomas M. Jessell},
  journal={Development},
  year={2003},
  volume={130 8},
  pages={1523-36}
}
In the developing spinal cord, motor neurons acquire columnar subtype identities that can be recognized by distinct profiles of homeodomain transcription factor expression. The mechanisms that direct the differentiation of motor neuron columnar subtype from an apparently uniform group of motor neuron progenitors remain poorly defined. In the chick embryo, the Mnx class homeodomain protein MNR2 is expressed selectively by motor neuron progenitors, and has been implicated in the specification of… CONTINUE READING