Regulation of monocyte interleukin-12 production by acute alcohol: a role for inhibition by interleukin-10.

@article{Girouard1998RegulationOM,
  title={Regulation of monocyte interleukin-12 production by acute alcohol: a role for inhibition by interleukin-10.},
  author={L Girouard and Pranoti Mandrekar and Donna Catalano and Gyongyi Szabo},
  journal={Alcoholism, clinical and experimental research},
  year={1998},
  volume={22 1},
  pages={211-6}
}
Acute ethanol treatment results in decreased antigen presentation capacity (Th1-type immunity) and elevated interleukin IL-10 (Th2 cytokine) production in human monocytes. Monocytes can contribute to both Th1 (IL-12) and Th2 (IL-10) immune responses via production of IL-12 and IL-10, respectively. Thus, we tested the hypothesis that acute alcohol treatment might affect Th1/Th2 immune balance by altering monocyte production of IL-12 and IL-10. Neither acute ethanol treatment alone (25 to 100 mM… CONTINUE READING