Regulation of mitotic spindle disassembly by an environmental stress-sensing pathway in budding yeast.

@article{Pigula2014RegulationOM,
  title={Regulation of mitotic spindle disassembly by an environmental stress-sensing pathway in budding yeast.},
  author={Adrianne Pigula and David G Drubin and Georjana Barnes},
  journal={Genetics},
  year={2014},
  volume={198 3},
  pages={1043-57}
}
Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilitates a role for She1 in late anaphase, when She1 contributes to microtubule depolymerization and shrinkage of spindle halves. By examining the genetic interactions of known spindle… CONTINUE READING
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