Regulation of mitogen-activated protein kinases by glutamate receptors.

  title={Regulation of mitogen-activated protein kinases by glutamate receptors.},
  author={John Q Wang and Eugene E. Fibuch and Limin Mao},
  journal={Journal of neurochemistry},
  volume={100 1},
Glutamate receptors regulate gene expression in neurons by activating intracellular signaling cascades that phosphorylate transcription factors within the nucleus. The mitogen-activated protein kinase (MAPK) cascade is one of the best characterized cascades in this regulatory process. The Ca(2+)-permeable ionotropic glutamate receptor, mainly the NMDA receptor subtype, activates MAPKs through a biochemical route involving the Ca(2+)-sensitive Ras-guanine nucleotide releasing factor, Ca(2… CONTINUE READING


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