Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit.

@article{Wei1998RegulationOM,
  title={Regulation of mitogen-activated protein kinase activation by the cytoplasmic domain of the alpha6 integrin subunit.},
  author={Jeanne Y Wei and L. M. Shaw and A M Mercurio},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 10},
  pages={
          5903-7
        }
}
We examined the possibility that the alpha6A and alpha6B cytoplasmic domain variants of the alpha6beta1 integrin differentially activate p42 and p44 mitogen-activated protein (MAP) kinases. P388D1 macrophages that express equivalent surface levels of either the alpha6Abeta1 or alpha6Bbeta1 integrin were used to examine this issue. Adhesion to laminin-1 mediated by the alpha6Abeta1 integrin triggered activation of a substantial fraction of total p42 and p44 MAP kinases as assessed using a… CONTINUE READING
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