Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.

@article{Pedersen2007RegulationOM,
  title={Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.},
  author={Stine Falsig Pedersen and Barbara Vasek Darborg and Maria Louise Rentsch and Maria Moeller Rasmussen},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={462 2},
  pages={
          195-201
        }
}
The mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK, play a major role in the regulation of pivotal cellular processes such as cell death/survival balance, cell cycle progression, and cell migration. MAPK activity is regulated by a three-tiered phosphorelay system, which is in turn regulated by a complex network of signaling events and scaffolding proteins. The ubiquitous plasma membrane Na(+)/H… CONTINUE READING
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