Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.

  title={Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1.},
  author={Michelangelo Campanella and Edward J Casswell and Stephanie Chong and Ziad Farah and Mariusz Roman Wieckowski and Andrey Y. Abramov and Andrew Tinker and Michael R Duchen},
  journal={Cell metabolism},
  volume={8 1},
When mitochondrial respiration is compromised, the F(1)F(o)-ATP synthase reverses and consumes ATP, serving to maintain the mitochondrial membrane potential (Delta psi(m)). This process is mitigated by IF(1). As little is known of the cell biology of IF(1), we have investigated the functional consequences of varying IF(1) expression. We report that, (1) during inhibition of respiration, IF(1) conserves ATP at the expense of Delta psi(m); (2) overexpression of IF(1) is protective against… CONTINUE READING
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