Regulation of mitochondrial processes: a target for heart failure.

  title={Regulation of mitochondrial processes: a target for heart failure.},
  author={Suresh Selvaraj Palaniyandi and Xin Qi and Gouri Yogalingam and Julio C B Ferreira and Daria Mochly-Rosen},
  journal={Drug discovery today. Disease mechanisms},
  volume={7 2},
Cardiac mitochondria, the main source of energy as well as free radicals, are vital organelles for normal functioning of the heart. Mitochondrial number, structure, turnover and function are regulated by processes such as mitochondrial protein quality control, mitochondrial fusion and fission and mitophagy. Recent studies suggest that abnormal changes in these mitochondrial regulatory processes may contribute to the pathology of heart failure (HF). Here we discuss these processes and their… CONTINUE READING

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