Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins

@article{GimnezCassina2015RegulationOM,
  title={Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins},
  author={Alfredo Gim{\'e}nez-Cassina and Nika N. Danial},
  journal={Trends in Endocrinology & Metabolism},
  year={2015},
  volume={26},
  pages={165-175}
}
Cells have evolved a highly integrated network of mechanisms to coordinate cellular survival/death, proliferation, differentiation, and repair with metabolic states. It is therefore not surprising that proteins with canonical roles in cell death/survival also modulate nutrient and energy metabolism and vice versa. The finding that many BCL-2 (B cell lymphoma 2) proteins reside at mitochondria or can translocate to this organelle has long motivated investigation into their involvement in normal… CONTINUE READING
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