Regulation of mitochondrial morphology by positive feedback interaction between PKCδ and Drp1 in vascular smooth muscle cell.

@article{Lim2015RegulationOM,
  title={Regulation of mitochondrial morphology by positive feedback interaction between PKCδ and Drp1 in vascular smooth muscle cell.},
  author={Soyeon Lim and Se-yeon Lee and Hyang-Hee Seo and Onju Ham and Changyeon Lee and Jun-Hee Park and Jiyun Lee and Minji Seung and Ina Yun and Sun Murray Han and Seahyoung Lee and Eunhyun Choi and K. T. Hwang},
  journal={Journal of cellular biochemistry},
  year={2015},
  volume={116 4},
  pages={648-60}
}
Dynamin-related protein-1 (Drp1) plays a critical role in mitochondrial fission which allows cell proliferation and Mdivi-1, a specific small molecule Drp1 inhibitor, is revealed to attenuate proliferation. However, few molecular mechanisms-related to Drp1 under stimulus for restenosis or atherosclerosis have been investigated in vascular smooth muscle cells (vSMCs). Therefore, we hypothesized that Drp1 inhibition can prevent vascular restenosis and investigated its regulatory mechanism… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…